According to early Muslim historians, the Meccans did not mind Muhammad practicing his religion, nor did they feel threatened by his promotion of it. This changed only after the self-proclaimed prophet began attacking their religion, including the customs and ancestors of the people. This was enough to stir up the resentment of the influential leaders of Mecca, who then mocked his humble background against his pretentious claims.
Still, Mecca at the time was a remarkably tolerant society. Muhammad was allowed to attack the local customs for thirteen years, even though the town's economy depended on the annual pilgrimage attended by visiting pagans, whose religion he actively disparaged.
At first, Muhammad was only successful with friends and family. After thirteen years, “the street preacher” could boast of only about a hundred determined followers, who called themselves Muslims. Outside of his wife, his first convert was his young cousin Ali. Another early convert was Abu Bakr, a wealthy merchant whose money and credulous acceptance of Muhammad can be credited with the survival of the fledgling cult.
Relations with the Meccans turned particularly sour after an episode known as "the Satanic Verses" in which Muhammad agreed to recognize the local gods in addition to Allah. This delighted the Meccans, who generously extended their welcome. But Muhammad soon changed his mind after his own people began to lose faith in him. He claimed that Satan had spoken through him, and he rescinded recognition of the Meccan gods.
The locals intensified their mockery of Muslims and made life particularly difficult for some of them.
But, in fact, the only Muslim whose life was truly in danger was that of Muhammad - after 13 years of being allowed to mock the local religion.
The death of his uncle, Abu Talib, in 619 left Muhammad without a protector against the Meccan leadership, which was gradually losing patience with him. The true agitator in this situation, however, is quite clearly Muhammad himself, as even Muslim historians note. Consider this account of what happened at Abu Talib's deathbed, as the Meccans implored him a final time for peace with his nephew:
Muhammad's chief adversary Abu Sufyan, with other sundry notables, went to Abu Talib and said: "You know the trouble that exists between us and your nephew, so call him and let us make an agreement that he will leave us alone and we will leave him alone; let him have his religion and we will have ours."
Muhammad rejected the offer of peaceful co-existence. His new religion was obviously intended to dominate the others, not be on equal standing with them. Meanwhile, the Muslims were beginning to become violentwith the people around them.
Muhammad's search for political alliance led him to make a treaty of war against the Meccans with the people of Medina, another Arab town far to the north. This was the last straw for the Meccans, who finally decided to capture Muhammad and put him to death.
The Meccans limited their deadly aggression to Muhammad himself. Thus Muhammad escapes his home by using his son-in-law, Ali, to trick his would-be assassins into thinking that they had him trapped. No harm was done to Ali or his wife, both of whom subsequently remained in the city for several days to complete the transfer of Muhammad's family business to Medina.
The year that Muhammad fled Mecca for Medina was 622, which marks the beginning of the Muslim calendar.

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